I have so many mods that the game shouldn't work. I have also noticed that when my Graphics Drivers need an update the game crashes at start up, so I need to update them and restart my computer, this works 99% of the time for me, so long as I have the mods installed and loaded in the correct order. I had one time where it was so bad that I had to Uninstall everything, and delete all mods (with the exception of modernweapons as the creator took it off nexus).
I suggest viewing the NMM Forums in regards to the matter. I had and continue to have the same issue. It is crashing due to conflicts either between the mods, or how you loaded them.